Online ISSN 2653-4983
JOURNAL of MULTISCALE NEUROSCIENCE
​ORIGINAL RESEARCH
Elizaveta Lugovskaya, Giulia Codagnone, Ivan Sanavia, Silvia Rey, Vanessa Terranova, Marcello Miceli, Marco A. Deriu and Jack Adam Tuszynski
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The progression of Aβ peptide aggregation in the brain has been suggested to play an important role in the pathogenesis and development of Alzheimer’s disease. The present study is intended to provide insight into the interactions between the zinc binding site of beta-amyloids and the zinc ion itself. It has been amply demonstrated that the absence of zinc bonded to the beta-amyloid may slow down the progression of the Alzheimer disease, so the goal is to provide an analysis of available drugs that can be repurposed, while waiting for the development of novel therapeutics. To this end, we address the issues of how and with what strength the existing compounds bind with beta-amyloid, potentially replacing or blocking zinc and preventing it from attaching to the amyloid itself. The analysis was performed using MOE software which, starting from a filtered database, made it possible to identify the drugs that were most likely to bind to the zinc binding site on beta-amyloid.
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CLINICAL REPORT
Zhang Sumei, Zhang Xiuhong, Wang Xiaoli, Hao Xinxin, Bai Jiangyan, and Zhao Liqiao
We conducted a study to examine how certain serum metabolic markers (reactive oxygen species (ROS), homocysteine (Hcy), and reduced glutathione (GSH)) impact the levels of IL-4 in patients with insomnia. The study involved 60 insomnia patients, including 20 with primary insomnia and 20 with somatopathy insomnia, aged 23-84 years with a mean age of 61.20 ± 12.59 years and a mean disease duration of 6.97 ± 8.45 years. There were 20 normal controls, 11 males and 9 females, aged 26-63 years, with an average age of 49.95 ± 10.52 years. We measured ROS levels using immunofluorescence, Hcy levels using enzyme-linked immunosorbent assay, and GSH levels using ELISA. The IL-4 level in serum was also detected by ELISA to assess the patient's immune function. Our analysis revealed that changes in ROS, Hcy, and GSH levels were associated with changes in IL-4 levels in serum. Therefore, early detection of serum metabolic changes in insomnia patients and proactive intervention can help reduce susceptibility to various infections and tumors.
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​PERSPECTIVE
Nancy J. Woolf and Jack A.Tuszynski
Alzheimer’s disease causes a progressive loss of memory and cognitive ability in the last decades of life. Clues to what causes these symptoms are suggested by the hallmark Alzheimer’s disease pathologies: amyloid plaques, tau tangles, and degeneration in the basal forebrain cholinergic system. Multiple treatment strategies for Alzheimer’s disease that attempt to remedy or remove these pathologies have met with limited success. We briefly review those strategies and hypothesize that the most effective treatment for Alzheimer’s disease might be gene therapy that replaces down-regulated proteins essential to the neuroplasticity underlying memory. Specifically, we suggest replacing tubulin isotypes that participate in memory-related structural change. This strategy stands to reverse Alzheimer’s disease memory deficits directly. Indirectly, this approach may halt or slow the formation of tau tangles and amyloid plaques. Microtubules lie at the crossroads of memory decline and Alzheimer’s disease pathology. Gene therapy may act as a "magic bullet" by restoring healthy microtubules essential for brain function. The proposed cascade suggests that microtubule disintegration precedes, rather than follows, tau tangle and plaque formation.
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​​CLINICAL CASE REPORT
A case of cerebral embolism associated with giant atrial myxoma
Wang Zhongyu, Zhang Sumei & Shi Peipei
A 61-year-old female was admitted to the Taiyan central hospital with occlusion of the right middle cerebral artery (MCA). A mucous-like thrombus was visualized during thrombus aspiration therapy prompting further examination towards possible source of the embolus. Bedside cardiac ultrasound revealed a left atrial myxoma with a size of approximately 5.6cm x 2.6cm. Due to risk of further embolization, including to the cerebral and coronary arteries, we provided 14 days of stable treatment in the acute phase. After the patient was stabilized from a neurological perspective, the patient underwent surgical resection of the atrial myxoma with good post-operative recovery. This case report points to the need for stabilization of the condition as a priority for surgery.
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ORIGINAL RESEARCH
Consciousness: a quantum optical effect in fluorescent protein pathways
R. R. Poznanski, J. Ali, N. Iannella & V. Sbnitnev
This paper gives a physical mechanism of embodied consciousness based on the dynamic organicity theory of consciousness. We use entropic pilot wave theory to describe the quantum dipole oscillations from dipole-bound delocalized (quasi-free) electrons in nonpolar cavities of aromatic amino acid residues and their fluorescent pathways that contain cavity quasipolariton condensates composed of quantized polarization waves of entangled photons. The behavior of oscillating molecular dipoles is influenced by the quantum nature of dynamic organicity, which causes energy fluctuations necessary to move delocalized electrons and create bare polaritons (quantized polarization waves). These quantized polarization waves correspond to photon quasiparticles interacting with water molecules to form quasipolaritons, softened by interacting with hydroxide ions (OH-) within crystal lattices of interfacial water H30. When [H3O+]=[OH−], the solution is neutral in hydrophobic cavities. In such nonpolar cavities, ‘wet wires’ are formed from hydrated ions (protons), and when displaced, they produce evanescent photons (non-radiative transitions in the absence of any source). Light emission occurs as protons (H+) diffuse in ‘wet wires’ due to recombination with hydroxide (OH-) ions, acting as ...
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BRIEF REPORT
A new pilot wave reinterpretation for quantum AI systems
Roumen Tsekov
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A new nonlinear Schrödinger equation is derived, which describes a cluster of bosons interacting via the strongest force. Its numerical solution points out that the cluster is stable only if the number of particles is exactly 131. The relevant kinetic and potential energies of the particles are also calculated and interrelated via the virial theorem. The developed concept is also applied to electrostatic forces.